Programme

Sunday   Monday   Tuesday   Wednesday   Thursday   Friday   Evening Workshops

Sunday 4th September 2016

16:00-19:00 Registration
19:00-21:00 Welcome Reception at the Museum of Science and Industry
   

Monday 5th September 2016

07:30-    Registration
   
08:45-09:00 Opening ceremony and welcome
  Christoph Tang and Ray Borrow
 

Meningococcal Vaccines (Chairs: Jun Wheeler and Mary Ramsay)

09:00-09:35 Plenary: Thirty years of meningitis
 

Professor David Salisbury

09:35-09:55 A definite barrier: Eliciting sterilizing immunity against Neisseria meningitidis within the respiratory tract
 

Scott Gray-Owen (Toronto, Canada)

09:55-10:15 Dissecting the function of the reduction modifiable protein, RmpM, from Neisseria meningitidis
 

Sunil Maharjan (Hertfordshire & Manchester, UK)

10:15-10:35 Invasive meningococcal disease in infants following the introduction of Bexsero® into the national immunisation programme in England
 

Shamez Ladhani (London, UK)

   
10:35-11:05 Tea & coffee break
 

Host Defences (Chairs: David Stephens and Lee Wetzler)

11:05-11:25 Two lytic transglycosylases in Neisseria gonorrhoeae impart resistance to killing by lysozyme and human neutrophils
 

Stephanie Ragland (Charlottesville, USA)

11:25-11:45 Effects of the cervical and vaginal microbiome on Neisseria gonorrhoeae infectivity
  Michael Apicella (Iowa City, USA)
11:45-12:05 Neisseria lactamica expresses a putative immunoglobulin D binding protein in its outer membrane that promotes binding to and activation of naive B cells via the B cell receptor, inducing proliferation
 

Andrew Vaughan (Southampton, UK)

12:05-12:25 Effect of vaccine-elicited antibodies on colonization of Neisseria meningitidis serogroup B and C strains in a human bronchial epithelial (16-HBE) cell culture model
 

Gregory Moe (Oakland, USA)

12:25-12:45 The detrimental role of C5aR in meningococcal sepsis
 

Kay Johswich (Würzburg, Germany)

   
12:45-14:00 Lunch
 

Molecular Physiology and Metabolism (Chairs: Caroline Genco and Joe Dillard)

14:00-14:20 The biology and molecular mechanism of the Neisseria meningitidis CRISPR-Cas9 pathway
 

Yan Zhang (Worcester, USA)

14:20-14:40 Meningococcal DNA binding and unwinding proteins
 

Tone Tønjum (Oslo, Norway)

14:40-15:00 Peptidoglycan recycling and toxic peptidoglycan fragment release in pathogenic and non-pathogenic Neisseria
 

Jia Mun Chan (Wisconsin, USA)

15:00-15:20 Acetyl phosphate-dependent protein acetylation in Neisseria gonorrhoeae and implications in biofilm formation and stability
 

Deborah Post (Novato, USA)

15:20 Session ends
   
15:20-18:00 Poster session with cheese and wine
   
19:30-21:30 Workshops
 

Workshop 1        Anti-microbials vs. gonorrhoeae: challenges and novel approaches

  Chair: Ann Jerse              
 

Workshop 2        How can we ensure safe working with pathogenic Neisseria?

  Chair: Stephen Taylor
 

Workshop 3        Human challenges

  Chair: Robert Read
 

Workshop 4        Modelling

  Chairs: Caroline Trotter and Hannah Christensen
   

Tuesday 6th September 2016

Top  
07:30- Registration
 

GSK Sponsored Satellite Symposium. Evaluating the Impact of 4CMenB*
© 2016 GlaxoSmithKline. All right reserved
Date of preparation: June 2016 VGBU/BEX/0024/16a
GlaxoSmithKline Biologicals SA., Rixensart, Belgium

08:00-08:25 4CMenB* international use
 

Angelika Banzhoff (GSK, Germany)

08:25-08:50 Pooled hSBA and individual seroprotection in infants
  Duccio Medini (GSK, Italy)
08:50-09:00 Conclusion and Q&A
 

All

*Meningococcal group B Vaccine (rDNA, component, adsorbed), internationally known as Bexsero®

   

Population Genetics (Dominique Caugant and Xin Wang)

09:15-09:50 Plenary:  Three decades of sequencing Neisseria: what have we learned?
 

Professor Martin Maiden

09:50-10:10 Whole genome characterization of the emerging epidemic meningococcal serogroup C and resurgence of serogroup W in Niger, 2015
 

Cecilia Kretz (Atlanta, USA)

10:10-10:22 Genome-wide association study of carriage versus invasive disease in Neisseria meningitidis
 

Sarah Earle (Oxford, UK)

10:22-10:34 Evolution of hypervirulent ST-4821 clonal complex (cc4821) Neisseria meningitidis in China through extensive homologous recombination
 

Mustapha Mustapha (Pittsburgh, USA)

10:34-10:54 Genomic characterisation of commensal Neisseria species
 

Odile Harrison (Oxford, UK)

   
10:54-11:25 Tea & coffee break
 

Genomics and Gene Regulation (Lori Snyder and Arie van der Ende)

11:25-11:45 Evolutionary events distinguish disease and carriage isolates of the clonal complex ST-32 during an outbreak of meningococcal disease in the Normandy, France
 

Julien Sevestre (Rouen & Paris, France)

11:45-12:05 The primary transcriptome of the human commensal pathogen Neisseria meningitidis and its interaction with the RNA chaperone Hfq
 

Christoph Schoen (Würzburg, Germany)

12:05-12:25 Identification of new therapeutic targets based on transcriptome analysis of gonococci during natural mucosal infection in men and women
 

Caroline Genco (Boston, USA)

12:25-12:45 Genetic adaptation contributing to increased gonococcal fitness during vaginal infection of CEACAM-humanized mice
 

Jessica Lam (Toronto, Canada)

12:45-13:05 The genes encoding the gonococcal transferrin binding proteins are regulated by MisR
 

Cynthia Cornelissen (Richmond, USA)

   
13:05-14:20 Lunch including meet the expert
 

Molecular & Cellular Biology (Chairs: Alexandra Schubert-Unkmeir and Guillaume Dumenil)

14:20-14:55 Plenary: The curious case of the evolution of the pathogenic Neisseria
 

Professor Hank Seifert

14:55-15:15 N. gonorrhoeae co-opts complement receptor 3 (CR3) for silent entry into human neutrophils
 

Asya Smirnov (Charlottesville, USA)

15:15-15:35 Neisseria gonorrhoeae manipulates human ectocervical and endocervical epithelial cells distinctively for infection
 

Wenxia Song (College Park, USA)

15:35-15:47 Identification of virulence-associated traits in Neisseria meningitidis Y serogroup
 

Chris Bayliss (Leicester, UK)

15:47-15:59 Investigating the function of pilE antisense RNA in Neisseria meningitidis
 

Felicia Tan (Oxford, UK)

   
15:59-16:30 Tea & coffee break
 

Bill & Melinda Gates scholarship (Chairs: Christoph Tang and Ray Borrow)

16:30-16:42 Meningococcal and pneumococcal meningitis in Western Burkina Faso after the introduction of group A meningococcal conjugate vaccine (2010) and 13-valent pneumococcal conjugate vaccine (2013)
 

Lassane Kabore (Bobo Dioulasso, Burkina Faso)

16:42-16:54 Profile of cytokine, chemokines, matrix metalloprotease-9 in cerebrospinal fluid profiles in meningococcal and pneumococcal meningitis patients in Ethiopia
 

Wude Woldemedhin (Addis Ababa, Ethiopia)

16:54-17:06 Molecular characterization of Neisseria meningitidis isolates recovered from 11 to 19 year-old meningococcal carriers in Salvador, Brazil
 

Ana Moura (Salvador, Brazil)

17:06-17:18         Cellular proteolytic targets and localisation of Meningococcal Neisseria Autotransporter Lipoprotein (NalP)
 

Osman Dufailu (Nottingham, UK)

17:18-17:30         Neisseria causes mitochondria damage in macrophages via PorB secretion on extracellular vesicles
 

Pankaj Deo (Melbourne, Australia)

17:30 Session ends
   
19:30-21:30 Workshops
 

Workshop 5        Home not alone- what’s new/to do in carriage and co-infection

 

Chair: Maggie So

 

Workshop 6        Genomics- an update

  Chair: Martin Maiden
 

Workshop 7        Delivering vaccines during times of austerity

  Chairs: Linda Glennie, Claire Wright and Jane Blewitt
 

Workshop 8        Outbreak! - What can be learnt from recent events in Africa?

  Chairs: Olivier Ronveaux and Ryan Novak
   

Wednesday 7th September 2016

Top  
07:30- Registration
   

Symposium: National outbreak of meningococcal serogroup W disease in the UK: new insights into epidemiology, disease characteristics and control strategies* (Chair: Ray Borrow, Public Health England, UK)

08:00-08:15 Epidemiology of invasive meningococcal disease and impact of the national immunisation programme
 

Shamez Ladhani (Public Health England, UK)

08.15-08.30 Matryoshka dolls: an outbreak within an outbreak
 

Jay Lucidarme (Public Health England, UK)

08.30-08.45 Clinical presentations and outcomes of newly emergent group W meningococcal strains
 

Helen Campbell (Public Health England, UK)

*The timeslot of the scientific session has been offered by Pfizer to Public Health England. Agenda and content of presentations have been developed independently by Public Health England with no input from Pfizer

   

Meningococcal Disease in Africa (Chairs: Carol Tevi-Benissan and Marc LaForce)

09:00-09:35 Plenary: Reflections on the control of epidemic meningitis in sub-Saharan Africa
 

Sir Brian Greenwood

09:35-09:55 Elimination of meningococcal A epidemics in Ghana: from research to public health
 

Abraham Hodgson (Accra, Ghana)

09:55-10:07 Pharyngeal carriage of Neisseria species in the African meningitis belt
 

Kanny Diallo (Bamako, Mali & Oxford UK)

10:07-10:19 Modeling alternative vaccination strategies to control N. meningitidis in Burkina Faso
 

Reza Yaesoubi (New Haven, USA)

10:19-10:31 Immunogenicity of the Meningitis Vaccine Project’s pentavalent MenACWYX polysaccharide conjugate vaccine MCV-5
 

Eilis Moran (Potters Bar, UK)

   
10:31-11:10 Tea & coffee break
 

Surface Structures (Chairs: Trevor Moraes and Vladimir Pelicic)

11:10-11:30 Neisserial filamentous phage: novel virulence determinant or bacterial Achilles Heel
 

Daniel Stein (College Park, USA)

11:30-11:50 Deciphering the glyco-interactome of Neisseria meningitidis
 

Tsitsi Mubaiwa (Gold Coast, Australia)

11:50-12:10 Alternative FH-binding receptors as complementary meningococcal vaccine antigens: identification of NspA residues involved in interaction with human FH
 

Rolando Pajon (Oakland & Indianapolis, US)

12:10-12:22 Use of vitronectin binding domains of the trimeric autotransporter Msf and the opacity protein Opc in vaccine design
 

Darryl Hill (Bristol, UK)

   
12:22- Free afternoon/cultural activities
   

Thursday 8th September 2016

Top  
08:00- Registration
   

Epidemiology (Jessica McNeil and Mignon Du Plessis)

09:00-09:12 Meningococcal carriage evaluation in response to a serogroup B meningococcal disease outbreak and mass vaccination campaign at a college — Rhode Island, 2015
 

Heidi Soeters (Atlanta, USA)

09:12-09:32 Expansion and diversification of the South American/UK meningococcal W:cc11 strain sublineage, and its association with an International World Scout Jamboree-associated outbreak
 

Kevin Scott (Glasgow, UK)

09:32-09:52 Increase in cases of urethritis due to non-groupable Neisseria meninigitidis (cc-11/ET-37) among men in Columbus, Ohio
 

Jose Bazan (Columbus, USA)

09:52-10:12 UKMENCAR4: a meningococcal carriage study in 21,000 teenagers to understand changing meningococcal epidemiology and evaluate National vaccination policy
 

Jenny MacLennan (Oxford, UK)

10:12-10:24 Molecular analysis of Neisseria meningitidisserogroup W in Argentina 2006-2012
 

Cecilia Sorhouet Pereira (Buenos Aires, Argentina)

10:24-10:36 Factors affecting meningococcal carriage density in individuals and variation over time
 

Hannah Christensen (Bristol, UK)

   
10:36-11:05 Tea & coffee break
   

Molecular & Cellular Biology (Chairs: James Moir and Thomas Rudel)

11:05-11:40 Plenary: Meningococcemia, a disease of the endothelial cells
 

Professor Xavier Nassif

11:40-12:00 Adhesion of Neisseria meningitidis to endothelial cells impairs the generation of the potent anticoagulant aPC through the ADAM10-mediated cleavage of the Endothelial Protein C Receptor
 

Hervé Lécuyer (Paris, France)

12:00-12:20 Identification of meningoccocal factors activating the ASM/ceramide system
 

Jérôme Becam (Würzburg, Germany)

12:20-12:32 A host cell-derived factor induces the dispersal of Neisseria meningitidis microcolonies
 

Sara Sigurlásdóttir (Stockholm, Sweden)

   
12:32-14:00 Lunch including meet the expert
   

Antibiotic Resistance (Susanne Jacobsson and William Shafer)

14:00-14:20 Regulation of the norM promoter in Neisseria gonorrhoeae
 

Corinne Rouquette-Loughlin (Atlanta, USA)

14:20-14:40 Epigenomic characterization of Neisseria gonorrhoeae isogenic mutants to examine the role of DNA methylation in antimicrobial resistance
 

David Trees (Atlanta, USA)

14:40-15:00 Identification of a spontaneously arising mutation in the TCA cycle enzyme, AcnB, that increases the biological fitness of ceftriaxone-resistant strains of Neisseria gonorrhoeae
 

Robert Nicholas (Chapel Hill, USA)

15:00-15:20 Antibacterial profile of a novel tricyclic topoisomerase inhibitor for the treatment of gonorrhoea
 

Neil Stokes (Alderley Edge, UK)

15:20-15:40 Whole genome sequencing for routine international molecular epidemiological surveillance of Neisseria gonorrhoeae: multidrug-resistant clones spreading in Europe in 2013
 

Magnus Unemo (Örebro, Sweden)

15:40-15:52 First report of meningococcal B vaccine failure in a young adult on long-term eculizumab
 

Sydel Parikh (London, UK)

15:52 Session ends
   
15:52-18:00 Poster session with pies and beer
19:00-    Gala dinner at Manchester Cathedral
   

Friday 9th September 2016

Top  
08:00- Registration
   

Surface Structures (Charlene Kahler and Jeremy Derrick)

09:00-09:12 The role of apolipoprotein N-acyl transferase (Lnt) in the processing of vaccine antigen, Factor H binding protein, of Neisseria meningitidis strain MC58 and its potential as a novel drug target
 

Ruth Griffin (Kingston upon Thames, UK)

09:12-09:32 Identification of Slam-dependent surface lipoprotein translocation in Gram-negative bacteria
 

Yogesh Hooda (Toronto, Canada)

09:32-09:52 A comparative structure/function analysis of two DUS-binding ComP orthologs defines a novel mode of sequence-specific DNA-binding
 

Vladimir Pelicic (London, UK)

09:52-10:12 Pilin N-terminal domain, a product of S-pilin cleavage, maintains transformation competence during gonococcal pilus phase variation
 

Kyle Obergfell (Chicago, USA)

10:12-10:24 Dynamics of cell sorting in early gonococcal biofilms
 

Berenike Maier (Köln, Germany)

   
10:24-10:55 Tea & coffee break
   

Gonococcal Vaccines (Michael Russell and Myron Christodoulides)

10:55-11:15 The Gonococcal Vaccine Initiative
 

Thomas Hiltke (Bethesda, USA)

11:15-11:27 Biology and function of the Neisseria gonorrhoeae Adhesin Complex Protein (Ng-ACP, NGO1981)
 

Hannia Almoncid Mendoza (Southampton, UK)

11:27-11:39 NGO1985 is a surface-exposed outer membrane lipoprotein involved in Neisseria gonorrhoeae cell envelope homeostasis and a novel gonorrhea vaccine candidate
 

Igor Wierzbicki (Corvallis, USA)

11:39-11:59 An experimental vaccine that generates protective immunity against genital infection with heterologous strains of Neisseria gonorrhoeae
 

Yingru Liu (Buffalo, USA)

11:59-12:19 Human studies in gonococcal infection: do failed vaccine trials and clinical/transmission studies shed light?
 

Peter Rice (Worcester, USA)

12:19-12:39 Effectiveness of a group B OMV meningococcal vaccine on gonorrhoea in New Zealand – a case control study
 

Helen Petousis-Harris (Auckland, New Zealand)

12:39-12:50 Closing ceremony and announcement of next meeting
  Christoph Tang and Ray Borrow
   
12:50 End of meeting
   

 

GSK Sponsored Satellite Symposium
Tuesday 6th September 2016
To view the programme, please click here

© 2016 GlaxoSmithKline. All right reserved
Date of preparation: June 2016 VGBU/BEX/0024/16a
GlaxoSmithKline Biologicals SA., Rixensart, Belgium

Please note: delegates must pre-register in order to attend the Welcome Reception to ensure entry to the venue

Registration for the workshops will open in March 2016. The workshops will be free of charge but places are limited and will be available on a first come, first served basis, open only to those who have registered for the meeting. All registered delegates will be sent notification once registration is open.

Registration and selection for the social tours will also open in March and registered delegates will be notified.

Evening Workshops – The Midland Hotel, Manchester
Top

Monday 19.30 – 21.30

Anti-microbials – novel challenges and approaches
Ann Jerse
Uniformed Services University of the Health Sciences
How can we ensure safe working with Pathogenic Neisseria?
Stephen Taylor
Public Health England
Human Challenges
Robert Read
University of Southampton
Modelling
Caroline Trotter
University of Cambridge
Hannah Christensen
University of Bristol
Tuesday 19.30 – 21.30 Home not alone – what’s new/to do in carriage and co-infection
Maggie So
University of Arizona
Genomics – an update
Martin Maiden
University of Oxford
Delivering vaccines during times of austerity
Claire Wright
Meningitis Research Foundation
Jane Blewitt
Meningitis Now
Outbreak! What can be learnt from recent events in Africa?
Olivier Ronveaux
World Health Organization
Ryan Novak
MenAfriNet Director

 

Registered delegates may attend one workshop per person free of charge. To register, please email your registration confirmation number (starting IPN6….), your name and any dietary requirements to Becky@hartleytaylor.co.uk with the name of the workshop you would like to attend. You will then receive confirmation of your workshop registration.

 

Manchester, UK

 

Manchester, UK